Welcome to BIO Beauty Care.com ~ Here we would like to lure you with current scientific information on how you may delay premature skin aging and age gracefully. And tell you about our BIOCUTIS ® natural, safe and effective skin care products made with a new powerful skin rejuvenation and immune support serum.
Skin aging is a natural biological process. Few clinically apparent changes occur in intrinsically aged skin until we are over 70 years of age at which point fine wrinkles become apparent. However, environmental aggression and genetic predisposition accelerates this process.
UV light is the most important damaging factor, leading to a process referred to as skin photoaging, precancerous skin lesions known as actinic keratosis or solar keratosis, and cancer.
The main mechanism of UV- induced photo-aging is a marked increase in the production of reactive oxygen species (ROS), which causes photo-oxidative damage and decreases cell migration and proliferation.
Photoaging affects the sun-exposed areas and exhibits both fine and deep wrinkles, roughness, dryness, laxity, small dilated blood vessels near the surface of the skin or mucous membranes, loss of tensile strength and pigmentation changes in the skin. There is also an increase in the development of benign and malignant abnormal proliferation of cells on photoaged skin.
Other pathological mechanisms involved in the process of skin aging are impaired remodeling capacity of the skin, reduced cell migration, adhesion and survival that shows as degradation of collagen and elastin and loss of the fibrillin-rich microfibrillar architecture which are key structural components providing for long-range elasticity, in the papillary dermis (the uppermost layer of the dermis).
Natural Anti Aging Products That Diminish Effects of Natural Aging and UV-Induced Damage
Regenerative properties of skin decrease with age, and thus search for products that can diminish the appearance and effects of either chronological aging or UV-induced photoaging is increasing dramatically in the last few years.
Among these natural products are fern leaves, green tea, or retinoids. The immune serum that powers BIOCUTIS products is a natural secretion from the mollusc Cryptomphalus, also known by zoologists as Helix aspersa, and by laymen as the humble brown garden snail, escargot or petit gris. This particular immune serum is endowed with rejuvenation properties when applied topically.
Clinical studies, not evaluated by the FDA as they are not at the stage required for a drug application, have demonstrated that the secretions induces skin regeneration after wound-healing impairment from acute radiodermatitis, and is beneficial in the regeneration of burnt skin and in the management of open wounds.
Scientific screening of the mollusk's secretion confirms that it stimulates fibroblast proliferation, the cells responsible for creating new collagen, elastin and the water holding molecules in healthy skin. It also induces a rearrangenment of the dynamic structures of cells (actin cytoskeleton).
The secretion exhibits a powerful antioxidant activity such as superoxide dismutase (SOD) and glutathione-S-transferase (GST) and multiple other antioxidant actions, acting at the level of free radical production and sequestering free radicals.
Moreover it also stimulates extracellular matrix assembly and the regulation of enzymatic metalloproteinase activities, which limits the extent of the damage during wounding and scar formation. And it restores health to skin damaged by UV A solar radiation.
A study just published, in April 2012, and available at the website of The Memorial Sloan-Kettering Cancer Center in New York, using different in vitro approaches has proven that the secretions increase fibroblast and keratinocyte migration and increase the expression of cell–cell and cell–substrate adhesion molecules in both cell types. You can read the abstract here.
The same research also demonstrated a role for the serum in cell survival signalling pathways, because it induces the expression of molecules related with this process (such as active b-catenin, FAK and phosphorylated FAK).
In laymen terms the serum acts on the skin to
- support the healing processes by nourishing, with complex molecules, our own immune system cells so that they are in the best shape to defend our organism from pathogens and foreign elements
- shield the skin from the effects of free radicals with powerful antioxidants
- inhibit the release of the biological irritants and inflammatory cascade involved in the onset of acne —which otherwise destroys normal cells and healthy connective tissues and creates those dreaded holes on your skin known as pitted or ice-pick acne scars
- repair damaged cells one-at-a-time, and soft tissues
- restore the proper level of moisture within the epidermis and the dermis (the cutis)
- dissolve clogged pores, melt hardened sebum in the pores
- "digest" all types of damaged and scar tissues with enzymes that break them down into their amino acid components, and then they may be used by the cells to rebuild the skin matrix
- rejuvenates the appearance of the skin and yields a beautiful, healthier looking skin.
It is NOT a very quick fix though, only long-term use yields significant improvements (5 to 6 months or more)
The reason for this is that sun damage tend to be very deep in the skin. To have an idea of scale: most human hairs are about 100-200 microns thick. Sun damage lesions normally extend between 800-2000 microns (.8mm-2mm) into the skin. This fact alone explains why most wrinkle and damaged skin treatments are minimally effective and why you have to be disciplined and apply the solution every day for months if you wish to enjoy a lifetime of healthy skin.
The serum embedded in a light cream or in a microdermabrasion cream (for dull skin, deep cleansing, dry abused skin and for scars) works as all things natural and whole work in nature: little by little, and ONLY if you are patient and apply the product with the serum every day, as directed, and for a period of time that will be determined by the damage your skin has endured (3 to 8 months is the median).
Either of the creams is an excellent prophylactic product for actinic keratosis as it hydrates the crusts and scales and they fall of your skin quickly. Those are damaged proteins in the skin and the small rough, scaly, crusty skin lesions and abnormal thick keratin deposits on the skin, are known by the terms actinic keratosis and "solar or senil keratosis".
Those lesions are caused by mutations in cells that have been damaged by long term overexposure to solar radiation and free radicals.
This is an important benefit because otherwise the accumulation of dead and damaged proteins and abnormal keratin cannot only end up in basal cell and squamous cell skin cancer or the more dangerous melanoma skin cancer, but also causes chronic inflammation with all its deleterious unhealthy effects.
Recent research is showing that inflammation, or as it is referenced nowadays: the process of "inflamm-aging", is not only the disorder at the base of acne & rosacea, dermatitis & eczema, and many other disorders affecting our skin but explains the now widely accepted phenomenon that aging is accompanied by a low-grade chronic, systemic up-regulation of the inflammatory response. And that the underlining inflammatory changes, not only affect the cells of our skin, but are also common to most age-associated diseases.
Sergio Giunta from The Clinical Laboratory & Molecular Diagnostics of the Geriatric Hospital in Ancona, Italy says
a review of the literature on Inflammaging suggests that, like acute inflammation is well known to be associated with the five cardinal features 1. rubor (redness), 2. tumor (swelling), 3. dolor (pain), 4. calor (warm), 5. functio lesa (loss of function), on the contrary, "inflamm-aging" is characterized by the complex set of five conditions which can be described as 1. low-grade, 2. controlled, 3. asymptomatic, 4. chronic, 5. systemic, inflammatory state.
Your health is dependent on your immune system and its ability to identify and repel your own damaged cells and 'foreign' invaders.
Our immune system ages with us and its inflamm-aging responses generate un-repaired cellular damage - the more damage, the earlier your quality of life will deteriorate as you age.
The cumulative effects of sun damaged skin, free radical oxidation, immoderate stress, heavy metal overload, and vitamin and mineral under nutrition wears us down, increasing our susceptibility to disease.
It is as if Mother Nature never anticipated that the immune system she designed for us would be so taxed; and now here she needs our help.
FORTUNATELY this little creature that lives with its skin exposed to the sun and the elements in a way that is similar to how we expose our face and other parts of our body to solar radiation and the elements, and with skin similar to human skin, secretes an immune system support serum that acts at the site of skin injuries, insults, trauma, solar or free radical damage; and stimulates the normal cycle of healthy skin regeneration.
It is the most surprising solution for the health of the skin, because it supports our skin in its role as an active organ in our defense and immunity, and it is also a very safe and effective topical solution for the skin concerns of people of all ages, skin types and skin conditions.
And with use over a period of 60 days it yields healthy skin that appears naturally luminous whatever its shade, from porcelain to richest ebony.
Nature Provides Many Examples of Regeneration
They include the newt's ability to regrow a severed limb and the ability of the snails --from which we collect the healing immune serum-- to regenerate their eyes, tentacles, and mouth when bitten by birds.
While in mammals and in particular in humans regeneration is limited to few restorative processes including new skin cells rapidly replacing the cells damaged from a laceration or from sunburn, wound healing, nerve and muscle regeneration following injury, growth of kidney and liver tissue, and regular re-population of the skin cells, and re-population of blood cells following the donation of bone marrow stem cells.
Also during embryonic development mammals and birds can regenerate such diverse tissues and structures as their skin and spinal cord.
However, humans can't perform the same trick of re-growing a severed limb like salamanders or newts can.
Regenerative Medicine: A Promising Field of Medical Research
But that might change because a new discipline, regenerative medicine, is focusing on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function resulting from any cause, including congenital defects, disease, trauma and aging.
It uses a combination of several technologies that move beyond therapies to cut out the bad or damaged cells and tissues and replace them by transplantation and replacement therapies (surgery), burn them out with laser heat or radiation therapy, or poison the bad or damaged cells with chemicals (chemotherapy) and acids (peeling exfoliators) faster than the good cells.
Among those technologies scientists screen the natural world and research what other people report as incredible discoveries. Or they search for soluble molecules, attempt to replicate complex molecules in the laboratory, and embark in gene therapy, stem cell transplantation, or tissue engineering that may consider one cell-at-a-time, and the reprogramming of cells and tissue types.
Regenerative medicine centered on human cells could become a disruptive technology because it would potentially replace a number of mayor macro molecular pharmaceuticals and medical prostheses.
In the meantime the good news is that the discovery of this immune serum, capable of supporting the immune system at the site of skin damage is changing the outlook for aging skin, damaged skin and inflamm-aging occurring in the epidermis and dermis, the cutis.
A Refreshing Outlook: The Easy Way to Healthier, Beautiful Looking Skin
This new discovery provides an easy way to get healthier looking skin, without any undesired side effects whatsoever. This novel and easy solution that addresses the root cause of damaged skin is secreted by a mollusk —that has a body with soft tissues very much like human skin with the same type of tissues: collagen and elastic skin fibers—
How It Works?
It works in a way similar to how another surprising mollusk, the oyster, coats an irritant —which causes a state of inflammation triggered by cell lining damage— by secreting a smooth, lustrous substance called nacre around the irritant to prevent it from disrupting its soft tissues. And in the process also yields something as precious as a beautiful Pearl: soft, healthy skin.
The serum is embedded in a cream that penetrates deeply into the skin
Once the snail secretions are collected, they are stabilized and sterilized by biotechnology and included in liposome vessels so that their enzymes, copper peptides, antioxidants, oxygen transport proteins and messenger and healing glycoproteins are not degraded by hydrolysis and can be readily available when applied topically to human skin.
Prestigious Dermatologists In the World Say It Works
Link 2008: Skin Regeneration Properties of Mollusk Secretion Copyright © 2007 S. Karger AG, Basel. Published at Synapse of The Memorial Sloan-Kettering Cancer Center in New York
Chemists are not yet able to use the complex machinery of the immune system of a living creature, which is capable of generating tremendous chemical diversity through the processes of recombination and somatic mutation, to create effective new molecular functions for skin regeneration in the laboratory, and thus the snail's serum is currently the best biological solution for skin rejuvenation and the improvement of the appearance of scar tissues.
This research published in English in January 2008 and the one of April 2012 published at Synapse, confirms previous reports in Spanish Dermatology Journals (1999-2001) that claim the secretion produced by land snails under stressful conditions have "skin-regenerative" properties.
It has multiple modes of antioxidant action, acting at the level of free radical production and also sequestering free radicals. Promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts, the rearrangement of the dynamic structures of cell's actin cytoskeleton, and stimulates Extra Cellular Matrix assembly.
Additional mechanisms involved in the regenerative effect of the secretion include the stimulation of extracellular matrix assembly and the action of regulatory proteins known as Tissue Inhibitors of Metalloproteinases (TIMPs) responsible for the reversible inhibition of metalloproteinase (MMP) enzymatic activities, which limits the extent of the damage during wounding and scar formation and attenuates the signs of aging by reducing the degenerative effects of excessive MMP activity.
Together, these effects provide an array of molecular mechanisms underlying the secretion's induced cellular regeneration and supports its use in skin regeneration treatments, BUT not for the treatment of diseases of the skin.
Discouraging Over-Zealous Immune System Responses that Attack Healthy Skin Tissues
The molecules in the biological serum nourish the cells and signal to them that they are being taken care of and need NOT respond to disturbing agents with uncontrolled inflammatory reactions, for they are being supplied with the proper proteins, enzymes and nutrients necessary to withstand the attack of bacteria and to trigger scar less healing.
Thus in a totally different way than our evolutionary drive has conditioned us humans to over-respond to those factors, from within, as the most effective means to thrive in an environment that was dominated by infectious bacteria.
For such was homo sapiens reality during millions of years and until society learned hygiene and modern science discovered antibiotics —which by the way have an anti-inflammatory effect that is now deemed to be a far more important effect for people who suffer severe acne and rosacea than it is the anti-biotic effect (which means anti-life) that kills bacteria.
Topical application of the serum created by this little creature, to prevent acne or soon after the first signs of acne lesions prevents the immune cells of your system from initiating the signaling cascade that leads to inflammatory reactions and healing through the scarring pathway. It accomplishes so by altering the local environment in a way that favors a scar-less healing pathway.
Scar treatment and removal of damaged tissues with BIOCUTIS products operates through a process called hydrolysation. By continued application on damaged tissues messenger molecules recognize damaged proteins and act in concert with enzymes that gently strip the skin to remove the build-up of damaged proteins and tissues.
These enzymes go to work like biological catalysts on each individual cell. They clean out the debris, open clogged pores, consume the dead material, open up the vascular system to bring new oxygen into the cells. And trigger and speed proliferation of fibroblasts and all the structural components of healthy skin including the water holding molecules, collagen and elastin skin fibers which finally get assembled in an orderly or orchestrated way, thus minimizing scars and marks.
"Skin is not in tight layers like everybody thinks". "We're not just onions, you can't just rip off a layer and voila - there's everything new. If you viewed a section of skin under a microscope it would look like a series of hills and valleys." says Dr. Danne Montague-King, the man who zapped Brad Pitt's scars and made Gwyneth Paltrow even prettier.
And when referring to the action of enzymes on skin he adds:
"The remaining cells are 'fed' or 'rebuilt' using the amino acids that are released from the metabolic digestion of the damaged and dead cells. This rejuvenates the skin too, for it's rather like charging a battery. The end result is like making the 'cleansers' of the cells strong again. If they're strong they'll dissolve things that aren't supposed to be there like abnormal scar tissues, pore plugs, excess and hardened sebum, injured and worn out cells, pollutants and free radicals. If they're weak they won't.
We have now described the problems of aging skin and the root causes of most skin problems, which is already the first part of a sound solution
The immoderate inflammatory response of our body to UVA damage, free radicals and injuries, the cell communicating ingredients and the enzymes that need to act in concert to strengthen and repair your skin.
They are the molecules that are capable of ‘dissolving’ damaged cells and scar proteins, trigger collagen and new elastin formation, and make the skin's structure strong by replenishing glycosaminoglycans, the water holding molecules in the dermis responsible for providing binding, hydrating and swelling pressure to tissues, enabling them to withstand compression and stretching forces and thus prevent sagging, tearing, and scarring of the deep layers of the skin.
Now you may stop procrastinating and go get the second half of the solution. Only then will you get your skin back to health and will be able to enjoy a lifetime of healthy skin and graceful aging
Call Us: 1-866-BIO-SKIN or 1-702-947-0567
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This product works excellent. I love the way it makes my skin feel! I now have my mom and brother using it. I originally ordered it for my brother who has acne and was constantly trying different things to help alleviate it. One day I was surfing the web and came across your site, and it sounded to good to be true. We all see a difference in our skin. The healing properties in your product are amazing! Thank you. Sincerely,
Melissa Shelly. PA, USA.
I was so impressed by the natural and immediate effectiveness of your product that I have let my mother and family members know about your product.
Barbara Osteika. Washington D.C., US
Your product, the BIOSKINEXFOL, is just great! I'm on my 5th jar! I’ve been your customer for more than a year now and this treatment is really amazing. My stretch marks are almost gone… it took a while but mark my words: They are almost GONE! And I don’t have to work hard to get the best results. I just apply your microdermabrasion product on my belly 3 times a week, massage the area with my finger tips until it is totally absorbed and that’s it! The little crystals fall off without me having to wash them away! I love it and I love you guys for sharing it! Thanks a lot.
Kelly Warren, Georgia.
I am extremely happy that I found this cream. It has really helped my skin. When I get blemishes, it clears it up quickly and leaves no scars. My skin tone is more even and smooth. Thank you!
Alisa Mathers. California, USA
After using BIOSKINBALM for two months the rhinophyma (acne rosacea) on my nose is now impossible to see but I can still feel a bit of it. My nose now looks like it did before I got the first rhinophyma in 1999. What is more my brother reports from New Zealand that after only two weeks his nose, which is much worse than mine, has lost much of its redness and this is only after two weeks use. I have been using the product for two months. The acne scars on my forehead have reduced dramatically and can now be concealed with only the Jane Iredale mineral powder. No longer need the camouflage cream.
Dorothea Glover. England.
My son burned 25% of his body; all 2rd degree burns. This cream has been a huge help in his road to recovery. The burns are mostly located on his back and arms. This cream is, once again, giving hope not only to me but to my little boy (13).
Annie C. Durham, NH, USA
"Your cream truly delivers what it says it can do. I have never found anything (and I tried ALOT of things) that could heal my face as well and quickly as your product. I had doubts when I first purchased it, but it has definitely performed (and so beautifully) above and beyond my expectations!! Send me some more!"
Karen M Gensheimer. IN, USA
"BIOSKINRELIEF is a great product! I am a white male who has suffered from painful, unsightly ingrown hairs from shaving for years. Until now, I've never been able to find anything to prevent them. I've been using BIOSKINRELIEF for about 5 months, and I rarely get ingrown hairs anymore and if I do get any, they are a lot milder than they used to be and heal much more quickly. My face now gets much less irritated from shaving and my complexion has greatly improved. Thanks!
Ben Campbell. Texas, USA
About two months ago my very beautiful 25 year old daughter was involved in a motorcycle accident which resulted in severe trauma to her right arm. Surgery restored the use of her arm, but the incisions and stitches were awful! Once the stitches were removed, we began using BIOSKINCARE.
It has only been two weeks but the difference in the appearance of the scaring is dramatic! I'm always leary of products that make claims such as yours but I was desperate to restore my daughter's physical appearance. I can't thank you enough for the outstanding results we've gotten so far - and in such a short time. Even her surgeon can't believe how well she's healing! Thank you again and I'm ordering another two jars today! Sincerely,
Trish Archambault, Windham NH, USA
This is my 2nd jar. I want to make sure I have one when I finish the first. I am impressed with this product. The first night I used it on my stretch marks I felt a gentle 'itching' like when something is healing. I can see results already. I have used the very expensive Strivectin, I think it's called. That is good, but this somehow is better because I am using it also on a surgical scar that nothing would help. I see already part of the scar has faded. I have tried everything to get rid of it.
Barbara Kafka. New York.
I just wanted to thank you guys for selling this cream. I have been living with stretch marks since I was 10 years old and have found it a bit depressing come summer time when everyone is pulling out their bikinis. I started using the cream last November and was applying it three times a day. As I finished my fourth bottle, I decided to take some time off since it had already faded my marks so drastically. Amazingly, they were still fading two months after my last use, so I assume using it once every other day will suffice. Plus, I love the fact that it is not greasy like other creams that I've tried. Thank you so much for this cream. Not only do I feel sexier, but my husband can't stop buying me lingerie. If you ever need a testimonial, I'd be happy to share my story. Once again, thanks for giving me self confidence.
Lea R. Brown. USA.
Scientific American - July 2002. Building better drugs from sugars. “Sugars modify many proteins and fats on cell surfaces and participate in such biological processes as immunity and cell-to-cell communication.
Mother Nature's Healing Powers - Natural Products As Healing Agents
For thousands of years people all over the world have used extracts from plants, frog skin, snail skin and mucus and other animals to promote healing of cutaneous wounds, heal burns and infectious diseases.
Biochemical analysis of the substance we use in our products shows it contains complex glycoconjugate molecules made mainly of sulfated sugar or carbohydrate chains (sugar= glyco), globular soluble proteins, uronic acids and oligoelements ( copper, zinc, calcium and iron ).
The major organic (i.e. carbon-containing) components of human cells are proteins, lipids, various carbohydrates and carbohydrate-containing molecules, and the nucleic acids (DNA and RNA). The carbohydrate-containing molecules can be quite complex; those in which carbohydrates are attached to proteins or lipids are called glycoconjugates. There are three major classes of glycoconjugates: glycoproteins, proteoglycans, and glycolipids.
Glyco means "sweet" and refers to monosaccharides, or sugars. The role of carbohydrates (sugars) in energy production has been long understood. However, their additional, crucial role in orchestrating the healthy structure and function of the body is a relatively new discovery that is the subject of a new bourgeoning field of science called the “ sweet science of glycobiology ”.
The efficacy of Helix Aspersa Müller extract in the healing of partial thickness burns: A novel treatment for open burn management protocols
This study evaluates the efficacy of Helix aspersa extract in an open wound management protocol for deep partial thickness (PT) facial burns and compares it to moist exposure burn ointment (MEBO).
Conclusion: Helix aspersa extract is a natural, safe and effective alternative treatment in open wound management of partial thickness burns in adults.
Read More: http://informahealthcare.com/doi/abs/10.1080/09546630802582037
The discoverer of a natural healing substance cannot patent the phenomenon
The main ingredient in the Biocutis line of products is a complex natural compound that cannot be replicated in even the most sophisticated laboratory on Earth. Because it is a naturally occurring compound and not a man-made substance it cannot be patented. This would only be possible if it were an isolate from a natural substance or a man made ingredient achieved through chemical reactions. Thus, by its very nature no one can claim exclusive rights of use granted by a patent of invention.
Our products are not endorsed by the Memorial Sloan-Kettering Cancer Center in New York but their published research validates the regenerative properties of the immune serum conclusively.